abstract：STUDY QUESTION:What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid f...

journal_title：BMJ (Clinical research ed.)

authors： Khoshnood B,Loane M,de Walle H,Arriola L,Addor MC,Barisic I,Beres J,Bianchi F,Dias C,Draper E,Garne E,Gatt M,Haeusler M,Klungsoyr K,Latos-Bielenska A,Lynch C,McDonnell B,Nelen V,Neville AJ,O'Mahony MT,Queisser-Luf

更新日期：2015-11-24 00:00:00

abstract：STUDY QUESTION:Does maternal smoking during pregnancy and exposure of infants to tobacco smoke at age 4 months increase the risk of caries in deciduous teeth? METHODS:Population based retrospective cohort study of 76 920 children born between 2004 and 2010 in Kobe City, Japan who received municipal health check-ups at...

journal_title：BMJ (Clinical research ed.)

authors： Tanaka S,Shinzawa M,Tokumasu H,Seto K,Tanaka S,Kawakami K

更新日期：2015-10-21 00:00:00

abstract：:Hepatitis B virus (HBV) is a global health problem that can lead to cirrhosis and hepatocellular carcinoma (HCC). Although HBV vaccination has reduced the prevalence Of HBV infection, the burden of disease remains high. Treatment with antiviral drugs reduces the risk of liver disease and the development of HCC, and it...

journal_title：BMJ (Clinical research ed.)

authors： Sundaram V,Kowdley K

更新日期：2015-10-21 00:00:00

abstract：:The high prevalence of cigarette smoking and tobacco related morbidity and mortality in people with chronic mental illness is well documented. This review summarizes results from studies of smoking cessation treatments in people with schizophrenia, depression, anxiety disorders, and post-traumatic stress disorder. It ...

journal_title：BMJ (Clinical research ed.)

authors： Tidey JW,Miller ME

更新日期：2015-09-21 00:00:00

abstract：OBJECTIVES:To compare the frequency of discrepancies in retracted reports of clinical trials with those in adjacent unretracted reports in the same journal. DESIGN:Blinded case-control study. SETTING:Journals in PubMed. POPULATION:50 manuscripts, classified on PubMed as retracted clinical trials, paired with 50 adja...

journal_title：BMJ (Clinical research ed.)

authors： Cole GD,Nowbar AN,Mielewczik M,Shun-Shin MJ,Francis DP

更新日期：2015-09-20 00:00:00

abstract：OBJECTIVE:To examine the association between warfarin treatment and longitudinal outcomes after ischemic stroke in patients with atrial fibrillation in community practice. DESIGN:Observational study. SETTING:Hospitals (n = 1487) participating in the Get With The Guidelines (GWTG)-Stroke program in the United States, ...

journal_title：BMJ (Clinical research ed.)

authors： Xian Y,Wu J,O'Brien EC,Fonarow GC,Olson DM,Schwamm LH,Bhatt DL,Smith EE,Suter RE,Hannah D,Lindholm B,Maisch L,Greiner MA,Lytle BL,Pencina MJ,Peterson ED,Hernandez AF

更新日期：2015-07-31 00:00:00

abstract：OBJECTIVE:To evaluate the relative efficacy of the World Health Organization 2005 campaign (WHO-5) and other interventions to promote hand hygiene among healthcare workers in hospital settings and to summarize associated information on use of resources. DESIGN:Systematic review and network meta-analysis. DATA SOURCES...

journal_title：BMJ (Clinical research ed.)

authors： Luangasanatip N,Hongsuwan M,Limmathurotsakul D,Lubell Y,Lee AS,Harbarth S,Day NP,Graves N,Cooper BS

更新日期：2015-07-28 00:00:00

abstract：OBJECTIVE:To accurately measure the incidence of gastric cancer among patients with gastric precancerous lesions, and to quantify the excess incidence in comparison with people with normal mucosa on endoscopy and a general population. DESIGN:Population based cohort study. SETTING:Population of Sweden using data from ...

journal_title：BMJ (Clinical research ed.)

authors： Song H,Ekheden IG,Zheng Z,Ericsson J,Nyrén O,Ye W

更新日期：2015-07-27 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of a two year exercise programme of progressive balance retraining in reducing injurious falls among women aged 75-85 at increased risk of falls and injuries and living in the community. DESIGN:Pragmatic multicentre, two arm, parallel group, randomised controlled trial. SETTING:2...

journal_title：BMJ (Clinical research ed.)

authors： El-Khoury F,Cassou B,Latouche A,Aegerter P,Charles MA,Dargent-Molina P

更新日期：2015-07-22 00:00:00

abstract：OBJECTIVES:To examine the prospective associations between consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice with type 2 diabetes before and after adjustment for adiposity, and to estimate the population attributable fraction for type 2 diabetes from consumption of sugar sweete...

journal_title：BMJ (Clinical research ed.)

authors： Imamura F,O'Connor L,Ye Z,Mursu J,Hayashino Y,Bhupathiraju SN,Forouhi NG

更新日期：2015-07-21 00:00:00

abstract：OBJECTIVE:To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol's iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. DESIGN:Systematic review and meta-analysis of dia...

journal_title：BMJ (Clinical research ed.)

authors： Fokom-Domgue J,Combescure C,Fokom-Defo V,Tebeu PM,Vassilakos P,Kengne AP,Petignat P

更新日期：2015-07-03 00:00:00

abstract：OBJECTIVE:To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes. DESIGN:Observational study. SETTING:Swedish National Diabetes Register, Sweden 2005-12. PARTICIPANTS:18,168 people with type 1 dia...

journal_title：BMJ (Clinical research ed.)

authors： Steineck I,Cederholm J,Eliasson B,Rawshani A,Eeg-Olofsson K,Svensson AM,Zethelius B,Avdic T,Landin-Olsson M,Jendle J,Gudbjörnsdóttir S,Swedish National Diabetes Register.

更新日期：2015-06-22 00:00:00

abstract：OBJECTIVE:To examine associations between varenicline and the incidence of a range of adverse outcomes. DESIGN:Population based cohort study using within person analyses to control for confounding by indication. SETTING:Whole population of Sweden. PARTICIPANTS:7,917,436 people aged 15 and over, of whom 69,757 were t...

journal_title：BMJ (Clinical research ed.)

authors： Molero Y,Lichtenstein P,Zetterqvist J,Gumpert CH,Fazel S

更新日期：2015-06-02 00:00:00

abstract：OBJECTIVE:To assess the waste of research related to inadequate methods in trials included in Cochrane reviews and to examine to what extent this waste could be avoided. A secondary objective was to perform a simulation study to re-estimate this avoidable waste if all trials were adequately reported. DESIGN:Methodolog...

journal_title：BMJ (Clinical research ed.)

authors： Yordanov Y,Dechartres A,Porcher R,Boutron I,Altman DG,Ravaud P

更新日期：2015-03-24 00:00:00

abstract：OBJECTIVE:To establish the extent to which systematic reviews and meta-analyses of individual participant data (IPD) are being used to inform the recommendations included in published clinical guidelines. DESIGN:Descriptive study. SETTING:Database maintained by the Cochrane IPD Meta-analysis Methods Group, supplement...

journal_title：BMJ (Clinical research ed.)

authors： Vale CL,Rydzewska LH,Rovers MM,Emberson JR,Gueyffier F,Stewart LA,Cochrane IPD Meta-analysis Methods Group.

更新日期：2015-03-06 00:00:00

abstract：OBJECTIVE:To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. DESIGN:Cohort study. SETTING:Patients registered with UK general practices contributing data to the QResearch database. PARTICIPANTS:238,963 patients...

journal_title：BMJ (Clinical research ed.)

authors： Coupland C,Hill T,Morriss R,Arthur A,Moore M,Hippisley-Cox J

更新日期：2015-02-18 00:00:00

abstract：OBJECTIVES:To estimate the prevalence and incidence of divorce among US physicians compared with other healthcare professionals, lawyers, and non-healthcare professionals, and to analyze factors associated with divorce among physicians. DESIGN:Retrospective analysis of nationally representative surveys conducted by th...

journal_title：BMJ (Clinical research ed.)

authors： Ly DP,Seabury SA,Jena AB

更新日期：2015-02-18 00:00:00

abstract：OBJECTIVES:To compare the effectiveness of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle with that of intrauterine insemination with controlled ovarian hyperstimulation in terms of a healthy child. DESIGN:Multicentre, open label, three arm, parallel group, ran...

journal_title：BMJ (Clinical research ed.)

authors： Bensdorp AJ,Tjon-Kon-Fat RI,Bossuyt PM,Koks CA,Oosterhuis GJ,Hoek A,Hompes PG,Broekmans FJ,Verhoeve HR,de Bruin JP,van Golde R,Repping S,Cohlen BJ,Lambers MD,van Bommel PF,Slappendel E,Perquin D,Smeenk JM,Pelinck MJ,

更新日期：2015-01-09 00:00:00

abstract：:Prediction models are developed to aid health care providers in estimating the probability or risk that a specific disease or condition is present (diagnostic models) or that a specific event will occur in the future (prognostic models), to inform their decision making. However, the overwhelming evidence shows that th...

journal_title：BMJ (Clinical research ed.)

authors： Collins GS,Reitsma JB,Altman DG,Moons KG

更新日期：2015-01-07 00:00:00

abstract：OBJECTIVE:To compare the mortality of patients in a palliative care unit on working days with that on weekends and public holidays. DESIGN:Retrospective database study. SETTING:Palliative care unit in Germany. POPULATION:All admissions to palliative care unit between 1 January 1997 and 31 December 2008. MAIN OUTCOM...

journal_title：BMJ (Clinical research ed.)

authors： Voltz R,Kamps R,Greinwald R,Hellmich M,Hamacher S,Becker G,Kuhr K,Gaertner J

更新日期：2014-12-16 00:00:00

abstract：:Ruben Meerman and Andrew Brown explain why the answer might not be what you expect. ...

journal_title：BMJ (Clinical research ed.)

authors： Meerman R,Brown AJ

更新日期：2014-12-16 00:00:00

abstract：OBJECTIVE:To investigate associations between maternal overweight and obesity and infant mortality outcomes, including cause-specific mortality. DESIGN:Population based cohort study. SETTING AND PARTICIPANTS:1,857,822 live single births in Sweden 1992-2010. MAIN OUTCOME MEASURES:Associations between maternal body ma...

journal_title：BMJ (Clinical research ed.)

authors： Johansson S,Villamor E,Altman M,Bonamy AK,Granath F,Cnattingius S

更新日期：2014-12-02 00:00:00

abstract：OBJECTIVE:To estimate the impact of a national primary care pay for performance scheme, the Quality and Outcomes Framework in England, on emergency hospital admissions for ambulatory care sensitive conditions (ACSCs). DESIGN:Controlled longitudinal study. SETTING:English National Health Service between 1998/99 and 20...

journal_title：BMJ (Clinical research ed.)

authors： Harrison MJ,Dusheiko M,Sutton M,Gravelle H,Doran T,Roland M

更新日期：2014-11-11 00:00:00

abstract：:The treatment of renal cell carcinoma (RCC) has changed greatly over the past 15 years. Progress in the surgical management of the primary tumor and increased understanding of the molecular biology and genomics of the disease have led to the development of new therapeutic agents. The management of the primary tumor ha...

journal_title：BMJ (Clinical research ed.)

authors： Jonasch E,Gao J,Rathmell WK

更新日期：2014-11-10 00:00:00

abstract：OBJECTIVE:To assess whether customised mobile phone reminders would improve adherence to therapy and thus decrease virological failure among HIV infected patients starting antiretroviral treatment (ART). DESIGN:Randomised controlled trial among HIV infected patients initiating antiretroviral treatment. SETTING:Three ...

journal_title：BMJ (Clinical research ed.)

authors： Shet A,De Costa A,Kumarasamy N,Rodrigues R,Rewari BB,Ashorn P,Eriksson B,Diwan V,HIVIND Study Team.

更新日期：2014-10-24 00:00:00

abstract：:In prospective studies, the prevalence of undiagnosed subclinical hypothyroidism in pregnant women ranges from 3% to 15%. Subclinical hypothyroidism is associated with multiple adverse outcomes in the mother and fetus, including spontaneous abortion, pre-eclampsia, gestational hypertension, gestational diabetes, prete...

journal_title：BMJ (Clinical research ed.)

authors： Negro R,Stagnaro-Green A

更新日期：2014-10-06 00:00:00

abstract：OBJECTIVE:To investigate the long term effectiveness of integrated disease management delivered in primary care on quality of life in patients with chronic obstructive pulmonary disease (COPD) compared with usual care. DESIGN:24 month, multicentre, pragmatic cluster randomised controlled trial SETTING:40 general prac...

journal_title：BMJ (Clinical research ed.)

authors： Kruis AL,Boland MR,Assendelft WJ,Gussekloo J,Tsiachristas A,Stijnen T,Blom C,Sont JK,Rutten-van Mölken MP,Chavannes NH

更新日期：2014-09-10 00:00:00

abstract：OBJECTIVE:To examine whether, according to the conclusions of a 2000 systematic review with meta-analysis on interventions to prevent pain from propofol injection that provided a research agenda to guide further research on the topic, subsequently published trials were more often optimally blinded, reported on children...

journal_title：BMJ (Clinical research ed.)

authors： Habre C,Tramèr MR,Pöpping DM,Elia N

更新日期：2014-08-26 00:00:00

abstract：OBJECTIVE:To re-evaluate the causal effect of interpregnancy interval on adverse birth outcomes, on the basis that previous studies relying on between mother comparisons may have inadequately adjusted for confounding by maternal risk factors. DESIGN:Retrospective cohort study using conditional logistic regression (mat...

journal_title：BMJ (Clinical research ed.)

authors： Ball SJ,Pereira G,Jacoby P,de Klerk N,Stanley FJ

更新日期：2014-07-23 00:00:00

abstract：OBJECTIVE:To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN:Mendelian randomisation meta-analysis of 56 epidemiological studies. PARTICIPANTS:261 991 individuals of European descent, including 20 259 c...

journal_title：BMJ (Clinical research ed.)

authors： Holmes MV,Dale CE,Zuccolo L,Silverwood RJ,Guo Y,Ye Z,Prieto-Merino D,Dehghan A,Trompet S,Wong A,Cavadino A,Drogan D,Padmanabhan S,Li S,Yesupriya A,Leusink M,Sundstrom J,Hubacek JA,Pikhart H,Swerdlow DI,Panayiotou

更新日期：2014-07-10 00:00:00

abstract：OBJECTIVE:To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits an...

journal_title：BMJ (Clinical research ed.)

authors： Maund E,Tendal B,Hróbjartsson A,Jørgensen KJ,Lundh A,Schroll J,Gøtzsche PC

更新日期：2014-06-04 00:00:00

abstract：:Screening for lung cancer with low dose computed tomography can reduce mortality from the disease by 20% in high risk smokers. This review covers the state of the art knowledge on several aspects of implementing a screening program. The most important are to identify people who are at high enough risk to warrant scree...

journal_title：BMJ (Clinical research ed.)

authors： Tammemagi MC,Lam S

更新日期：2014-05-27 00:00:00

abstract：OBJECTIVE:To systematically review and describe currently available approaches to supporting maintenance of weight loss in obese adults and to assess the evidence for the effectiveness of these interventions. DESIGN:Systematic review with meta-analysis. DATA SOURCES:Medline, PsycINFO, Embase, and the Cochrane Central...

journal_title：BMJ (Clinical research ed.)

authors： Dombrowski SU,Knittle K,Avenell A,Araújo-Soares V,Sniehotta FF

更新日期：2014-05-14 00:00:00

abstract：OBJECTIVES:To examine the association between environmental exposure to takeaway food outlets, takeaway food consumption, and body weight, while accounting for home, work place, and commuting route environments. DESIGN:Population based, cross sectional study, using data on individual participants' diet and weight, and...

journal_title：BMJ (Clinical research ed.)

authors： Burgoine T,Forouhi NG,Griffin SJ,Wareham NJ,Monsivais P

更新日期：2014-03-13 00:00:00

abstract：OBJECTIVE:To assess whether a strategy of endovascular repair (if aortic morphology is suitable, open repair if not) versus open repair reduces early mortality for patients with suspected ruptured abdominal aortic aneurysm. DESIGN:Randomised controlled trial. SETTING:30 vascular centres (29 UK, 1 Canadian), 2009-13. ...

journal_title：BMJ (Clinical research ed.)

authors： IMPROVE Trial Investigators.,Powell JT,Sweeting MJ,Thompson MM,Ashleigh R,Bell R,Gomes M,Greenhalgh RM,Grieve R,Heatley F,Hinchliffe RJ,Thompson SG,Ulug P

更新日期：2014-01-13 00:00:00

abstract：OBJECTIVE:To compare perinatal outcomes in births of women with versus without a history of bariatric surgery. DESIGN:Population based matched cohort study. SETTING:Swedish national health service. PARTICIPANTS:1,742,702 singleton births identified in the Swedish medical birth register between 1992 and 2009. For eac...

journal_title：BMJ (Clinical research ed.)

authors： Roos N,Neovius M,Cnattingius S,Trolle Lagerros Y,Sääf M,Granath F,Stephansson O

更新日期：2013-11-12 00:00:00

abstract：OBJECTIVES:To assess the effects of treatments for non-metastatic invasive squamous cell carcinoma (SCC) of the skin using evidence from observational studies, given the paucity of evidence from randomised controlled trials. DESIGN:Systematic review of observational studies. DATA SOURCES:Medline, Embase, to December ...

journal_title：BMJ (Clinical research ed.)

authors： Lansbury L,Bath-Hextall F,Perkins W,Stanton W,Leonardi-Bee J

更新日期：2013-11-04 00:00:00

abstract：OBJECTIVE:To examine whether total joint arthroplasty of the hip and knee reduces the risk for serious cardiovascular events in patients with moderate-severe osteoarthritis. DESIGN:Propensity score matched landmark analysis. SETTING:Ontario, Canada. PARTICIPANTS:2200 adults with hip or knee osteoarthritis aged 55 or...

journal_title：BMJ (Clinical research ed.)

authors： Ravi B,Croxford R,Austin PC,Lipscombe L,Bierman AS,Harvey PJ,Hawker GA

更新日期：2013-10-30 00:00:00

abstract：:A 40 year old man presents with a 1 cm tender soft swelling in the lateral neck region. This developed seven days after the onset of a tonsillitis episode that has now resolved. He has a 20 pack-year smoking history and consumes minimal alcohol. Examination is otherwise normal. ...

journal_title：BMJ (Clinical research ed.)

authors： Dwivedi RC,Masterson L,Alam M,Jani P

更新日期：2013-10-28 00:00:00

abstract：OBJECTIVE:To assess strategies for advice on analgesia and steam inhalation for respiratory tract infections. DESIGN:Open pragmatic parallel group factorial randomised controlled trial. SETTING:Primary care in United Kingdom. PARTICIPANTS:Patients aged ≥ 3 with acute respiratory tract infections. INTERVENTION:889 p...

journal_title：BMJ (Clinical research ed.)

authors： Little P,Moore M,Kelly J,Williamson I,Leydon G,McDermott L,Mullee M,Stuart B,PIPS Investigators.

更新日期：2013-10-25 00:00:00